Chonkit Lio

Education

Bachelor of Pharmacy

Chinese Medicine, Macau University of Science and Technology, Macau, China

Master of Pharmacy

Traditional Chinese Medicine, Macau University of Science and Technology, Macau, China

Contact Information

Research Interests

Zmpste24 is a metallopeptidase involved in the processing of prelamin A and the clearance of translocon clogging. Mutations in Zmpste24 lead to laminopathies similar to those caused by mutations in lamin A. I am interested in how Zmpste24 mutations affects cell migration and whether the effects are related to its functions in prelamin A processing.

Publications

• Wang QL, Huang WX, Zhang PJ, Chen L, Lio CK, Zhou H, Qing LS, Luo P. Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1α) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic. Mikrochim Acta, 2019 Dec 18; 187(1):61.
• Lio CK, Luo JF, Shen XY, Dai Y, Machado J, Xie Y, Yao YD, Yu Y, Liu JX, Yao XS, Luo P, Zhou H. Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1. Biochem Pharmacol, 2020 Mar; 173:113639.
• Wang TT, Lio CK, Huang H, Wang RY, Zhou H, Luo P, Qing LS. A feasible image-based colorimetric assay using a smartphone RGB camera for point-of-care monitoring of diabetes. Talanta, 2020 Jan 1; 206:120211.
• Yao YD, Shen XY, Machado J, Luo JF, Dai Y, Lio CK, Yu Y, Xie Y, Luo P, Liu JX, Yao XS, Liu ZQ, Zhou H,. Nardochinoid B Inhibited the Activation of RAW264.7 Macrophages Stimulated by Lipopolysaccharide through Activating the Nrf2/HO-1 Pathway. Molecules, 2019 Jul 6; 24(13). pii:E2482.
• Luo JF, Shen XY, Lio CK, Dai Y, Cheng CS, Liu JX, Yao YD, Yu Y, Xie Y, Luo P, Yao XS, Liu ZQ, Zhou H,. Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages. Front Pharmacol, 2018 Sep 4; 9:911.
• Shen XY, Qin DP, Zhou H, Luo JF, Yao YD, Lio CK, Li HB, Dai Y, Yu Y, Yao XS. Nardochinoids A-C, Three Dimeric Sesquiterpenoids with Specific Fused-Ring Skeletons from Nardostachys chinensis. Org Lett, 2018 Sep 21; 20(18):5813-5816.
• Li Y, Ren X, Lio C, Sun W, Lai K, Liu Y, Zhang Z, Liang J, Zhou H, Liu L, Huang H, Ren J, Luo P. A chlorogenic acid-phospholipid complex ameliorates post-myocardial infarction inflammatory response mediated by mitochondrial reactive oxygen species in SAMP8 mice. Pharmacol Res, 2018 Apr; 130:110-122.
• Zhou H, Liu JX, Luo JF, Cheng CS, Leung EL, Li Y, Su XH, Liu ZQ, Chen TB, Duan FG, Dong Y, Zuo YH, Li C, Lio CK, Li T, Luo P, Xie Y, Yao XJ, Wang PX, Liu L. Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis. Biochem Pharmacol, 2017 Oct 15; 142:133-144.